??? ??????? ?? ?????? ?? ????? ?????? ? ??? ???? ???? ??????? ?? ????????? ??? ???? ? ???? ???? ????? ???????????? ????? ????????? ??? ????? ???? ??? ?????????? ????? ???? ????? ?????? ???????? ?? ????? ??????? ??????????? ????? ????? ?????? ??? ???? ?????????? ?????? ???? ????? ???????? ????For patients on prior opioid therapy, start out OPANA ER